Given the air is different in an airplane than on ground I wonder whether it is advisable to use the Resperate while in flight (I spend a lot of time on 10-hour-plus flights)?

I will double check on this for you, but I'm sure it is ok due to the fact that the cabins are pressurized.
Breathe Easy!
Marguerite (IMG:style_emoticons/default/cool.gif)

I just was told that the cabin air pressure on a jet is approximately the same as at 8,000 feet. So, unless you live up on a tall mountain somewhere, the air pressure is significantly different than on the ground. Accordingly, another way to ask my question is whether it is safe to use Resperate when one is temporarily at an altitude of 8,000 feet (assuming my information about cabin pressure is correct)?

Dear Jay K,
"High altitude in mountains involves both low air pressure and low oxygen concentration. Even under the extreme conditions of the Himalaya RESPeRATE found to be beneficial regarding the physiological problems associated with such conditions.
Although low air pressure may have an effect on the delivery of oxygen to the tissues (to which our body adjusts) there is no reason why RESPeRATE, which merely affects breathing movements, would create any problem. The Himalaya experience suggests the opposite." - Dr Benjamin Gavish.
Also, we have many people who use the RESPeRATE while in flight.
Breathe Easy!
Marguerite (IMG:style_emoticons/default/cool.gif)